Fields »
ABOUT
HELP
BLOG
S100B

GENERAL INFORMATION

Gene name

 S100B

Gene description

 S100 calcium binding protein B

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, adipose tissue)
GTEx:Group enriched (hypothalamus, hippocampus, cerebellum, caudate, cerebral cortex)
FANTOM5:Tissue enhanced (brain, cerebellum, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression mainly in CNS, peripheral nerves and subset of lymphoid cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA015768 , CAB000073 , CAB078196
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Soft tissue

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hypothalamus, hippocampus, cerebellum, caudate, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, cerebellum, hippocampus)

GENE INFORMATION

Gene name

 S100B (HGNC Symbol)

Synonyms

 S100beta

Description

 S100 calcium binding protein B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 46598962 - 46605208

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160307 (version 83.38)

Entrez gene

 6285

UniProt

 P04271 (UniProt - Evidence at protein level)

neXtProt

 NX_P04271

Antibodypedia

 S100B antibodies

PROTEIN BROWSER
S100B-001
S100B-002
S100B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
S100B-001
ENSP00000291700
ENST00000291700
P04271 [Direct mapping]
Protein S100-B
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005102 [receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007409 [axonogenesis]
GO:0007417 [central nervous system development]
GO:0007611 [learning or memory]
GO:0007613 [memory]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0048156 [tau protein binding]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048708 [astrocyte differentiation]
GO:0050786 [RAGE receptor binding]
GO:0050806 [positive regulation of synaptic transmission]
GO:0051384 [response to glucocorticoid]
GO:0051597 [response to methylmercury]
GO:0060291 [long-term synaptic potentiation]
GO:0071456 [cellular response to hypoxia]
GO:2001015 [negative regulation of skeletal muscle cell differentiation]
Show all
 92 aa
10.7 kDa 		No 0
S100B-002
ENSP00000356038
ENST00000367071
A8MRB1 [Direct mapping]
Protein S100-B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0008270 [zinc ion binding]
Show all
 94 aa
10.3 kDa 		No 0
S100B-003
ENSP00000380769
ENST00000397648
P04271 [Direct mapping]
Protein S100-B
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007409 [axonogenesis]
GO:0007417 [central nervous system development]
GO:0007611 [learning or memory]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0048156 [tau protein binding]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050786 [RAGE receptor binding]
Show all
 92 aa
10.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.