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SYNPO

GENERAL INFORMATION

Gene name

 SYNPO

Gene description

 Synaptopodin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including glomeruli in kidney, skeletal muscle and CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 3 antibodies.
HPA034631 , CAB033265 , CAB037325
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SYNPO (HGNC Symbol)

Synonyms

 KIAA1029

Description

 Synaptopodin (HGNC Symbol)

Entrez gene summary

 Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).[supplied by OMIM, Mar 2008]

Chromosome

 5

Cytoband

 q33.1

Chromosome location (bp)

 150601080 - 150659220

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171992 (version 83.38)

Entrez gene

 11346

UniProt

 Q8N3V7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N3V7

Antibodypedia

 SYNPO antibodies

PROTEIN BROWSER
SYNPO-001
SYNPO-002
SYNPO-003
SYNPO-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYNPO-001
ENSP00000302139
ENST00000307662
Q8N3V7 [Direct mapping]
Synaptopodin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005923 [bicellular tight junction]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0032233 [positive regulation of actin filament bundle assembly]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0045211 [postsynaptic membrane]
GO:0051492 [regulation of stress fiber assembly]
Show all
 903 aa
96.4 kDa 		No 0
SYNPO-002
ENSP00000377789
ENST00000394243
Q8N3V7 [Direct mapping]
Synaptopodin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005923 [bicellular tight junction]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0032233 [positive regulation of actin filament bundle assembly]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0045211 [postsynaptic membrane]
GO:0051492 [regulation of stress fiber assembly]
Show all
 929 aa
99.5 kDa 		No 0
SYNPO-003
ENSP00000428378
ENST00000522122
Q8N3V7 [Direct mapping]
Synaptopodin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005923 [bicellular tight junction]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0032233 [positive regulation of actin filament bundle assembly]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0045211 [postsynaptic membrane]
GO:0051492 [regulation of stress fiber assembly]
Show all
 929 aa
99.5 kDa 		No 0
SYNPO-004
ENSP00000429268
ENST00000519664
Q8N3V7 [Direct mapping]
Synaptopodin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005923 [bicellular tight junction]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0032233 [positive regulation of actin filament bundle assembly]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0045211 [postsynaptic membrane]
GO:0051492 [regulation of stress fiber assembly]
Show all
 685 aa
73.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.