Tissue expression of BCAP31 - Summary - The Human Protein Atlas

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BCAP31

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	BCAP31
Gene description	B-cell receptor-associated protein 31
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA003906 , CAB015350 , CAB015424
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	BCAP31 (HGNC Symbol)
Synonyms	6C6-Ag, BAP31, CDM, DXS1357E
Description	B-cell receptor-associated protein 31 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153700497 - 153724697
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185825 (version 83.38)
Entrez gene	10134
UniProt	P51572 (UniProt - Evidence at protein level)
neXtProt	NX_P51572
Antibodypedia	BCAP31 antibodies

PROTEIN BROWSER

BCAP31-001	BCAP31-002	BCAP31-004	BCAP31-005	BCAP31-006	BCAP31-007	BCAP31-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCAP31-001 ENSP00000343458 ENST00000345046	P51572 [Direct mapping] B-cell receptor-associated protein 31 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005784 [Sec61 translocon complex] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0005887 [integral component of plasma membrane] GO:0006886 [intracellular protein transport] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0012501 [programmed cell death] GO:0016020 [membrane] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1904154 [positive regulation of retrograde protein transport, ER to cytosol] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] Show all	246 aa 28 kDa	No	3
BCAP31-002 ENSP00000392330 ENST00000458587	P51572 [Direct mapping] B-cell receptor-associated protein 31 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005784 [Sec61 translocon complex] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0005887 [integral component of plasma membrane] GO:0006886 [intracellular protein transport] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007283 [spermatogenesis] GO:0012501 [programmed cell death] GO:0016020 [membrane] GO:0030136 [clathrin-coated vesicle] GO:0032403 [protein complex binding] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0032580 [Golgi cisterna membrane] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0042288 [MHC class I protein binding] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0070973 [protein localization to endoplasmic reticulum exit site] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1904154 [positive regulation of retrograde protein transport, ER to cytosol] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] Show all	313 aa 34.8 kDa	No	3
BCAP31-004 ENSP00000394270 ENST00000416815	C9JSP1 [Direct mapping] B-cell receptor-associated protein 31 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0006886 [intracellular protein transport] GO:0016021 [integral component of membrane] Show all	182 aa 20.7 kDa	No	3
BCAP31-005 ENSP00000409888 ENST00000429550	C9JQ75 [Direct mapping] B-cell receptor-associated protein 31 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0006886 [intracellular protein transport] GO:0016021 [integral component of membrane] Show all	187 aa 21.2 kDa	No	3
BCAP31-006 ENSP00000400345 ENST00000442093	C9J0M4 [Direct mapping] B-cell receptor-associated protein 31 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0006886 [intracellular protein transport] GO:0016021 [integral component of membrane] Show all	188 aa 21.3 kDa	No	3
BCAP31-007 ENSP00000402342 ENST00000430088	C9JM14 [Direct mapping] B-cell receptor-associated protein 31 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0006886 [intracellular protein transport] GO:0016021 [integral component of membrane] Show all	138 aa 16 kDa	No	3
BCAP31-009 ENSP00000389740 ENST00000423827	C9JMD7 [Direct mapping] B-cell receptor-associated protein 31 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0006886 [intracellular protein transport] GO:0016021 [integral component of membrane] Show all	178 aa 20.2 kDa	No	3

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