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MBP

GENERAL INFORMATION

Gene name

 MBP

Gene description

 Myelin basic protein

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 22
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (hippocampus, hypothalamus, cerebral cortex, caudate)
FANTOM5:Group enriched (brain, hippocampus, caudate, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in oligodendrocytes in CNS and peripheral nerves.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA049222 , CAB002300
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, hypothalamus, cerebral cortex, caudate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, hippocampus, caudate, cerebellum)

GENE INFORMATION

Gene name

 MBP

Synonyms

Description

 Myelin basic protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called ""Golli-MBP"") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q23

Chromosome location (bp)

 76978827 - 77133683

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197971 (version 83.38)

Entrez gene

 4155

UniProt

 P02686 (UniProt - Evidence at protein level)

neXtProt

 NX_P02686

Antibodypedia

 MBP antibodies

PROTEIN BROWSER
«
MBP-001
MBP-002
MBP-004
MBP-005
MBP-006
MBP-007
MBP-015
MBP-016
MBP-019
MBP-024
MBP-028
MBP-031
MBP-032
MBP-033
MBP-034
MBP-035
MBP-037
MBP-039
MBP-048
MBP-049
MBP-050
MBP-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MBP-001
ENSP00000352667
ENST00000359645
P02686 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007268 [synaptic transmission]
GO:0007417 [central nervous system development]
GO:0008366 [axon ensheathment]
GO:0019911 [structural constituent of myelin sheath]
GO:0021762 [substantia nigra development]
GO:0033269 [internode region of axon]
GO:0042552 [myelination]
GO:0043025 [neuronal cell body]
GO:0043218 [compact myelin]
GO:0071944 [cell periphery]
Show all
 186 aa
20.2 kDa 		No 0
MBP-002
ENSP00000372025
ENST00000382582
P02686 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007268 [synaptic transmission]
GO:0007417 [central nervous system development]
GO:0008366 [axon ensheathment]
GO:0019911 [structural constituent of myelin sheath]
GO:0021762 [substantia nigra development]
GO:0033269 [internode region of axon]
GO:0042552 [myelination]
GO:0043025 [neuronal cell body]
GO:0043218 [compact myelin]
GO:0071944 [cell periphery]
Show all
 197 aa
21.5 kDa 		No 0
MBP-004
ENSP00000380961
ENST00000397863
P02686 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007268 [synaptic transmission]
GO:0007417 [central nervous system development]
GO:0008366 [axon ensheathment]
GO:0019911 [structural constituent of myelin sheath]
GO:0021762 [substantia nigra development]
GO:0033269 [internode region of axon]
GO:0042552 [myelination]
GO:0043025 [neuronal cell body]
GO:0043218 [compact myelin]
GO:0071944 [cell periphery]
Show all
 197 aa
21.5 kDa 		No 0
MBP-005
ENSP00000380958
ENST00000397860
P02686 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007268 [synaptic transmission]
GO:0007417 [central nervous system development]
GO:0007568 [aging]
GO:0008366 [axon ensheathment]
GO:0009636 [response to toxic substance]
GO:0019911 [structural constituent of myelin sheath]
GO:0021762 [substantia nigra development]
GO:0032570 [response to progesterone]
GO:0033269 [internode region of axon]
GO:0034612 [response to tumor necrosis factor]
GO:0042552 [myelination]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043209 [myelin sheath]
GO:0043218 [compact myelin]
GO:0046689 [response to mercury ion]
GO:0050771 [negative regulation of axonogenesis]
GO:0061024 [membrane organization]
GO:0070542 [response to fatty acid]
GO:0071944 [cell periphery]
Show all
 197 aa
21.5 kDa 		No 0
MBP-006
ENSP00000380964
ENST00000397866
P02686 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007268 [synaptic transmission]
GO:0007417 [central nervous system development]
GO:0008366 [axon ensheathment]
GO:0019911 [structural constituent of myelin sheath]
GO:0021762 [substantia nigra development]
GO:0033269 [internode region of axon]
GO:0042552 [myelination]
GO:0043025 [neuronal cell body]
GO:0043218 [compact myelin]
GO:0071944 [cell periphery]
Show all
 171 aa
18.6 kDa 		No 0
MBP-007
ENSP00000380963
ENST00000397865
P02686 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007268 [synaptic transmission]
GO:0007417 [central nervous system development]
GO:0008366 [axon ensheathment]
GO:0019911 [structural constituent of myelin sheath]
GO:0021762 [substantia nigra development]
GO:0033269 [internode region of axon]
GO:0042552 [myelination]
GO:0043025 [neuronal cell body]
GO:0043218 [compact myelin]
GO:0071944 [cell periphery]
Show all
 160 aa
17.3 kDa 		No 0
MBP-015
ENSP00000437063
ENST00000498683
E9PNZ1 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 86 aa
9.5 kDa 		No 0
MBP-016
ENSP00000405882
ENST00000447114
C9J6H1 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 101 aa
11.1 kDa 		No 0
MBP-019
ENSP00000380973
ENST00000397875
A8MZH3 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 181 aa
19.7 kDa 		No 0
MBP-024
ENSP00000380967
ENST00000397869
H7BYR8 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 236 aa
25.7 kDa 		No 0
MBP-028
ENSP00000435641
ENST00000526111
E9PJ72 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 149 aa
16.2 kDa 		No 0
MBP-031
ENSP00000436830
ENST00000528160
E9PQE7 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 68 aa
7.6 kDa 		No 0
MBP-032
ENSP00000346545
ENST00000354542
F8WEU6 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 73 aa
7.9 kDa 		No 0
MBP-033
ENSP00000435243
ENST00000527041
E9PKX9 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 108 aa
11.9 kDa 		No 0
MBP-034
ENSP00000463164
ENST00000583798
J3QKN5 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 41 aa
4.5 kDa 		No 0
MBP-035
ENSP00000462374
ENST00000581878
J3KS94 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 159 aa
17.4 kDa 		No 0
MBP-037
ENSP00000463403
ENST00000578193
J3QL64 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 157 aa
17.1 kDa 		No 0
MBP-039
ENSP00000463137
ENST00000578873
J3QKL5 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 171 aa
18.9 kDa 		No 0
MBP-048
ENSP00000463780
ENST00000579129
J3QQK6 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 253 aa
27.7 kDa 		No 0
MBP-049
ENSP00000462223
ENST00000580402
P02686 [Direct mapping]
Myelin basic protein
A0A024R384 [Target identity:100%; Query identity:100%]
Myelin basic protein, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007268 [synaptic transmission]
GO:0007417 [central nervous system development]
GO:0008366 [axon ensheathment]
GO:0019911 [structural constituent of myelin sheath]
GO:0021762 [substantia nigra development]
GO:0033269 [internode region of axon]
GO:0042552 [myelination]
GO:0043025 [neuronal cell body]
GO:0043218 [compact myelin]
GO:0071944 [cell periphery]
Show all
 304 aa
33.1 kDa 		No 0
MBP-050
ENSP00000462734
ENST00000585201
J3KT01 [Direct mapping]
Myelin basic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019911 [structural constituent of myelin sheath]
Show all
 180 aa
19.4 kDa 		No 0
MBP-201
ENSP00000348273
ENST00000355994
P02686 [Direct mapping]
Myelin basic protein
A0A024R384 [Target identity:100%; Query identity:100%]
Myelin basic protein, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007268 [synaptic transmission]
GO:0007417 [central nervous system development]
GO:0008366 [axon ensheathment]
GO:0019911 [structural constituent of myelin sheath]
GO:0021762 [substantia nigra development]
GO:0033269 [internode region of axon]
GO:0042552 [myelination]
GO:0043025 [neuronal cell body]
GO:0043218 [compact myelin]
GO:0071944 [cell periphery]
Show all
 304 aa
33.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.