THE HUMAN PROTEIN ATLAS BLOG

Wellness Profiling program presented at the EMBL organised symposium - From Single to Multi-omics

2017-11-10
Human Protein Atlas omics Wellness project

On Nov 13, Dr Linn Fagerberg has presented a talk entitled "Integrative omics profiling within the Swedish SCAPIS SciLifeLab (S3) Wellness Profiling program" at the EMBO|EMBL symposia "From Single to Multi-omics: Applications and Challenges in Data Integration" in Heidelberg, Germany. The talk focused on the integration of data retrieved from the analysis of biological samples collected within the SCAPIS project using different technological platforms. On the same day, Dr Fredrik Edfors participated in the poster session with a poster entitled "Gene specific correlation between protein and RNA"...Read more


Conference - plenary lecture at Clinical Proteomics, Postgenome Medicine, Moscow, Russia.

2017-10-27
Conference Human Protein Atlas Precision medicine Tissue Atlas

Dr Cecilia Lindskog, Director of the Tissue Atlas in the Human Protein Atlas, will present a plenary lecture on October 31 entitled "The Human Protein Atlas - implications for human biology and precision medicine" on the Clinical Proteomics, Postgenome Medicine conference in Moscow, Russia. Dr Lindskog is highlighted as one of the key speakers of the conference. The 300+ international participants include medical advisors, scientists and business representatives, and the focus of the conference is to open the fields of "omics" science (genomics, transcriptomics, proteomics, metabolomics) to clinical practioners...Read more


Chan Zuckerberg funds pilot project within the Human Protein Atlas

2017-10-19
Cell Atlas Chan Zucherberg Initiative Human Protein Atlas

The Human Protein Atlas at the Science for Life Laboratory (SciLifeLab) are teaming up with the Chan Zuckerberg Initiative to strengthen research in cell biology and proteomics.

The Chan Zuckerberg Initiative, which was founded by Facebook founder Mark Zuckerberg and his wife, Dr. Priscilla Chan, provides financial and engineering support for the Human Cell Atlas, an ambitious international collaboration that aims to create a reference atlas of all cells in the healthy human body as a resource for studies of health and disease...Read more


Mathias Uhlen honored with the Swedish Research Award 2017

2017-09-21
Human Protein Atlas Precision medicine

Research!Sweden foundation

The Swedish Research Award 2017 has been awarded to Professor Mathias Uhlen by the foundation Research!Sweden. On the September 25th Mathias Uhlen will receive the award for research accomplishments regarding mapping of human proteins within the Human Protein Atlas. The mission of the Research!Sweden foundation is to raise awareness regarding the importance of medical research - for health and prosperity by honoring every year one researcher or politician with the award.

Anna Nilsson Vindefjärd general secretary of Research!Sweden motivates the nomination "Mathias Uhlén's research is extremely valuable both for today and future precision medicine...Read more


Conference - Human Protein Atlas lectures and posters on the 16th HUPO World Congress

2017-09-14
Conference Human Protein Atlas

Next week on the 17th to 21th of September, the human proteome organization (HUPO), is hosting the 16th HUPO World Congress in Dublin, Ireland. Several Human Protein Atlas-associated researchers will attend the meeting and represent the project in various sessions, including plenary and invited lectures, oral presentations and poster sessions.

HUPO is an international scientific organization representing and promoting proteomics through international cooperation and collaborations by fostering the development of new technologies, techniques and training...Read more


Symposium celebrating 100-years anniversary Knut and Alice Wallenberg foundation

2017-09-08
Conference Human Protein Atlas Subcell Atlas

The Knut and Alice Wallenberg Foundation (KAW) cellebrates 100-years anniversary of funding research within natural sciences, technology and medicine. Since 1917, when KAW was established, grants have been awarded to enpower both scientific research and education beneficial for the society. Today the foundation is one of the largest private funders of scientific research in Europe.

The KAW funded Molecular Life Science - anniversary symposium is organised by the Royal Academy of Sciences together with KTH - The Royal Institute of Technology, Karolinska Institute and Stockholm University...Read more


Conference - Invited lecture at the 29th European Congress of Pathology

2017-08-30
Conference Human Protein Atlas Pathology Atlas

This weekend Amsterdam is hosting the 29th European Congress of Pathology (ECP 2017). Fredrik Ponten, Co-Founder and Clinical Director of the Human Protein Atlas program, will present a lecture on September 3 entitled "Tissue-based map of the human proteome as tool for pathology". The focus of this year´s European congress will be "Pathology for Patient Care" highlighting the added value of the pathology science and discipline in providing care and improving health outcomes for patients and population. The congress is expected to provide updates on all aspects of diagnostic and molecular pathology...Read more


New Pathology Atlas maps the genes involved in cancer and promotes personalized cancer medicine

2017-08-17
Cancer Human Protein Atlas Pathology Atlas

Pathology Atlas principle

A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns of individual cancers observed in the study strongly reinforces the need for personalized cancer treatment based on precision medicine. In addition, the systems level approach used to construct the Pathology Atlas demonstrates the power of "big data" to change how medical research is performed.

The dream of personalized treatment for cancer patients takes a major step forward today with the launch by Swedish researchers of the Human Pathology Atlas...Read more


The Human Protein Atlas selected as European core resource in life science by ELIXIR

2017-08-09
Human Protein Atlas Precision medicine

ELIXIR is an intergovernmental organisation that brings together life science resources from across Europe. These resources include databases, software tools, training materials, cloud storage and supercomputers. The goal of ELIXIR is to coordinate these resources so that they form a single infrastructure. This infrastructure makes it easier for scientists to find and share data, exchange expertise, and agree on best practices. Ultimately, it will help them gain new insights into how living organisms work.

On July 25, 2017, ELIXIR announced the selected list of ELIXIR Core Data Resources...Read more


Conference - keynote lecture at Europe-Korea Conference on Science and Technology

2017-07-15
Drug development Human Protein Atlas

Mathias Uhlen from the Human Protein Atlas will on July the 27 present a keynote lecture on the Europe-Korea Conference on Science and Technology (EKC2017) entitled "The Human Protein Atlas - implications for human biology, drug development and precision medicine"...Read more


The Human Cell Atlas selected as one of 10 emerging technologies to make a change to society

2017-06-27
Cell Atlas Human Protein Atlas Technologies

This week, Scientific American announced ten emerging technologies with innovations that are on the verge of changing society. One of the technologies selected was the Human Cell Atlas, which aims to integrate research exploring the building-blocks of human cells using new emerging technologies. The list of ten emerging technologies was compiled in a collaboration between Scientific American and the World Economic Forum's Expert Network with suggestions from members of the Expert Network, the forum's Global Future Councils and Scientific American's board of advisers...Read more


Conference - keynote lecture at CYTO2017 in Boston

2017-06-12
Cell Atlas CYTO2017 Human Protein Atlas Single cell analysis

Emma Lundberg Director of the Human Cell Atlas, will present a keynote lecture on June 14th, entitled ”The Cell Atlas: A subcellular map of the human proteome” on the 32ndCongress of the International Society for Advancement of Cytometry in Boston, USA.

On this occassion, the CYTO Congress together with the Human Protein Atlas have organized a challenge for analysis of the images from the Cell Atlas, culminating in presentation of results in the final conference session, where participants will present their analytical methods and findings...Read more


Keynote lecture - 6th Pharmaceutical Science World

2017-05-19
Drug development Human Protein Atlas

  

Mathias Uhlen, Director of the Human Protein Atlas program, will present a keynote lecture on May 23 entitled "Tissue-based protein profiles – implications for human biology, drug development and precision medicine " on the 6th Pharmaceutical Science World Congress (PSWC 2017) in Stockholm, Sweden.

The focus of this year´s world congress will be " Future medicine for one world " including research and development related to systems approaches to drug discovery development and clinical usage...Read more


Meet the site director

2017-02-07
Antibody Human Protein Atlas Secretome

Hanna Tegel

Today we meet Hanna Tegel, site director at the AlbaNova site of the Human Protein Atlas, and group leader of the Antigen and Antibody Factory group. She has been with the Human Protein Atlas from the very beginning, and her career has evolved alongside the project.

– I took my M.Sc. in biotechnology at KTH – the Royal Institute of Technology here in Stockholm, and in the end of my education I complemented it with some physiology at the Karolinska Institute. As a part of this course I did a project at KTH, and when it was time for me to do my masters thesis I turned to the same professor. Now he was involved in the start-up of the Human Protein Atlas project...Read more


On childhood asthma and protein profiles in plasma

2016-05-24
Antibody Suspension Bead Array Asthma Human Protein Atlas Plasma

Protein levels of CCL5, HPGDS and NPSR1 in plasma

In a recent publication in European Journal of Allergy and Clinical Immunology, researchers use an affinity proteomics approach to analyze plasma profiles of a 362 proteins in 154 children with persistent or intermittent asthma and controls. To this end, antibody suspension bead arrays developed within the Human Protein Atlas was used.

Asthma is a common chronic childhood disease with many different phenotypes that need to be identified. Asthma affects approximately 300 million people worldwide and is characterized by bronchial hyperresponsiveness and reversible expiratory airflow limitation...Read more


Site director with a fascination for patterns

2016-05-16
Human Protein Atlas Immunocytochemistry Interview Microarray Proteomics RNA-seq Tissue Atlas

Cecilia Lindskog, site director of the Tissue Atlas

Time has come for the second interview with a researcher within the Human Protein Atlas project. Today we meet Cecilia Lindskog, site director of the Tissue Atlas.

– I have a Master of Science in Biomedicine and a Doctor of Philosophy in pathology from the Faculty of Medicine, Uppsala University. I joined the Human Protein Atlas project in 2006, and also have industry experience in the biotechnology industry, from Oncomark Ltd, Dublin, Ireland.

Cecilia Lindskog´s main research interests have always been understanding the biology and functions of different organs, and the underlying mechanisms leading to cancer and other diseases...Read more


Aquaporin 9 expression in human tissue

2016-05-10
Hepatocellular Carcinoma Human Protein Atlas Liver Tissue Atlas

Protein expression of aquaporin 9 in normal tissues

In a very recent paper in Journal of Histochemistry and Cytochemistry , with researchers from the Human Protein Atlas, it is shown that the expression of aquaporin 9 is limited in normal tissues, and high membranous expression is observed only in hepatocytes.

Aquaporin 9 is known to facilitate hepatocyte glycerol uptake. Murine aquaporin 9 protein expression has been verified in liver, skin, epididymis, epidermis and neuronal cells using knockout mice.

One goal of the current study was to systematically explore the distribution of aquaporin 9 expression in humans...Read more


Meet the author: Mingdong Zhang

2016-05-03
Human Protein Atlas Mouse Brain Atlas Spinal Cord

Mingdong Zhang

As a follow up from last week´s blog post, on Jan Mulder and his work, we now present the most recent publication from his lab, on the anatomical distribution of neuronal calcium-binding proteins 1 and 2 (NECAB1/2) in rodent and human spinal cord.

Mingdong Zhang is the first author of the study and a PhD student registered in the Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics (MBB) at Karolinska Institutet.

– But much of my actual work is carried out in the Department of Neuroscience...Read more


Analysis of 32 human organs and tissues

2016-04-20
Brain Human Protein Atlas Testis Tissue Atlas

A network plot of the tissue enriched (red) and group enriched (orange) genes

In the Human Protein Atlas, there are 32 human organs and tissues analyzed. 2489 of the genes have significantly higher expression in one tissue compared to all other tissue types. Analysis show that testis is the organ with the largest number of tissue-enriched genes, with 1057 genes classified as testis enriched. The specific events and alterations of cell structure during spermatogenesis, and the fact that sperm has the ability to survive outside the male body may explain why testis has the largest number of enriched genes.

The organ with the second highest number of enriched genes is the brain with 381 enriched genes...Read more


Project Discovery - Day 1 results

2016-03-16
CCP Citizen Science EVE Online Human Protein Atlas MMOS Project Discovery Proteome

Fig. 1. Confusion matrix of gamer predictions versus HPA predictions. Here columns represent votes of gamers. Confusions occurring with a frequency below 1% are set to black for clarity.

Thanks Science Fans!

The response to Project Discovery has been amazing and overwhelming. You have taken to the game in a way none of us expected. Keep it up!

First, in an effort to stream line our interactions with you we have created a number of official social media outlets:

EVE forums: We have a number of official accounts we will respond to questions with.Twitter: HPA_Discovery - dedicated to posting updates, announcements and all things Project Discovery. Twitter is severely character limited so it's difficult to answer questions there.Reddits: /r/EVE and /r/projectdiscovery - We will be here for support as well...Read more