THE HUMAN PROTEIN ATLAS BLOG

Focusing on Prognostic Genes in Lung Cancer

2017-10-13
Cancer Immunohistochemistry Lung cancer Pathology Atlas TCGA

Figure 1. Immunohistochemical staining of MPC1 using antibody HPA045119 shows a differential expression pattern in samples from lung cancer patients.

As part of the release of the Pathology Atlas, the Human Protein Atlas Blog will each week present a brief and informative summary where we highlight genes with prognostic association in different cancer forms. If you missed last week's blog post about prognostic genes in ovarian cancer, click here.

This week, we will focus on Lung cancer one of the deadliest cancers in the world today.

Lung cancer patients have a poor outcome with a 5-year survival rate of 13.6% in men and 19.4% in women. Late diagnosis and lack of effective treatments are considered to contribute to poor prognosis...Read more


Awareness for prostate cancer

2017-09-27
European Prostate Cancer Awareness Day Immunohistochemistry Pathology Atlas Prostate cancer Prostate Cancer Awareness Month TCGA

Figure 1. Immunohistochemical staining of ODF2 using antibody HPA001874 shows differential expression in samples from prostate cancer patients.

As part of the release of the Pathology Atlas, the Human Protein Atlas Blog presents brief and informative summaries of most cancers, and highlight genes with prognostic association in the different cancer forms. The Pathology Atlas is an open access database which includes quantitative transcriptomics data and spatial proteomics data of the major human cancer types that have been analyzed using a systems level approach.

We focus on prostate cancer in this week's blog post to highlight Prostate Cancer Awareness Month in North America and the European Prostate Cancer Awareness Day on the 27th of September...Read more


Focusing on prognostic genes in breast cancer

2017-09-07
Breast Cancer Cancer Immunohistochemistry Pathology Atlas TCGA

Figure 1. Immunohistochemical staining of CBX3 using antibody HPA004902 shows a differential nuclear expression in samples from breast cancer patients.

The Pathology Atlas, recently published in Science presents key proteins associated with different cancer types. This week, we will focus on breast cancer and proteins related to cancer prognosis.

Breast cancer is the most common invasive cancer form in women worldwide. The cancer can roughly be classified as ductal or lobular breast cancer depending on the origin. The majority of breast cancers develop sporadically, but for 5-10% of patients there is an inherited factor associated with increased breast cancer risk, namely the BRCA1 and BRCA2 genes. Women with abnormal BRCA1 or BRCA2 have higher risk of developing breast cancer...Read more


Conference - Invited lecture at the 29th European Congress of Pathology

2017-08-30
Conference Human Protein Atlas Pathology Atlas

This weekend Amsterdam is hosting the 29th European Congress of Pathology (ECP 2017). Fredrik Ponten, Co-Founder and Clinical Director of the Human Protein Atlas program, will present a lecture on September 3 entitled "Tissue-based map of the human proteome as tool for pathology". The focus of this year´s European congress will be "Pathology for Patient Care" highlighting the added value of the pathology science and discipline in providing care and improving health outcomes for patients and population. The congress is expected to provide updates on all aspects of diagnostic and molecular pathology...Read more


Highlighting the prognostic genes in colon cancer

2017-08-25
Cancer Colorectal cancer Immunohistochemistry Pathology Atlas

Figure 1. Immunohistochemical staining of JDP2 protein using HPA059511 antibody shows a differential expression in samples from colorectal cancer patients.

Last week the Human Protein Atlas portal was updated. The result was The Pathology Atlas - an interactive atlas where the expression of specific genes and their influence on patient survival in the 17 major cancer types can be explored. The Pathology Atlas includes quantitative genome-wide transcriptomics data (RNA-seq) of the 17 cancers coupled with clinical outcome and spatial proteomics data (immunohistochemistry) of more than 15,000 proteins...Read more


New Pathology Atlas maps the genes involved in cancer and promotes personalized cancer medicine

2017-08-17
Cancer Human Protein Atlas Pathology Atlas

Pathology Atlas principle

A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns of individual cancers observed in the study strongly reinforces the need for personalized cancer treatment based on precision medicine. In addition, the systems level approach used to construct the Pathology Atlas demonstrates the power of "big data" to change how medical research is performed.

The dream of personalized treatment for cancer patients takes a major step forward today with the launch by Swedish researchers of the Human Pathology Atlas...Read more


NIFK interacts with the proliferation marker Ki-67

2017-05-24
Cancer Cancer Atlas Image of the month Immunohistochemical staining KI-67 Melanoma Pathology Atlas Skin cancer

Skin with growth of a cutaneous melanoma expressing the protein NIFK.

Melanoma is a common form of cancer in the skin and among skin cancers it is the most deadly form. Melanoma originates from cells of melanocytic origin and most typically begins as a small intraepidermal tumor (melanoma in situ). As the tumor continues to grow and progress, tumor cells invade the epidermis and eventually spread to regional lymph nodes and subsequently via hematogenic spread to distant organs. Tumor thickness of the primary tumor is the most important determining prognostic factor and thus is early discovery of key importance for survival...Read more


AACR Annual Meeting 2017

2017-04-04
Conference Pathology Atlas

Cecilia Lindskog and Borbala Katona in the booth

A team from the Human Protein Atlas is attending the AACR Annual Meeting 2017 in Washington DC right now. This year, the meeting covers topics on research propelling cancer prevention and cures, and the Human Protein Atlas is represented by a booth where our team gives a personalized go-through of the Atlas to everyone who is interested in our open access resource. In addition, a demo version of a new Pathology Atlas can also be previewed in our booth. It will contain information on the prognostic genes and proteins for clinical outcome of the major cancer types in humans...Read more