Tissue expression of GRN - Summary - The Human Protein Atlas

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GRN

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GRN
Gene description	Granulin
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues, high expression in subsets of immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA008763 , HPA028747 , CAB019394
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GRN (HGNC Symbol)
Synonyms	CLN11, PCDGF, PGRN
Description	Granulin (HGNC Symbol)
Entrez gene summary	Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	44345086 - 44353102
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000030582 (version 83.38)
Entrez gene	2896
UniProt	P28799 (UniProt - Evidence at protein level)
neXtProt	NX_P28799
Antibodypedia	GRN antibodies

PROTEIN BROWSER

GRN-001	GRN-002	GRN-003	GRN-005	GRN-006	GRN-007	GRN-008	GRN-009	GRN-010	GRN-011	GRN-013	GRN-016	GRN-017	GRN-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRN-001 ENSP00000053867 ENST00000053867	P28799 [Direct mapping] Granulins Acrogranin Paragranulin Granulin-1 Granulin-2 Granulin-3 Granulin-4 Granulin-5 Granulin-6 Granulin-7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001835 [blastocyst hatching] GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005739 [mitochondrion] GO:0007165 [signal transduction] GO:0007566 [embryo implantation] GO:0008083 [growth factor activity] GO:0010976 [positive regulation of neuron projection development] GO:0032355 [response to estradiol] GO:0035988 [chondrocyte proliferation] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0048488 [synaptic vesicle endocytosis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0060179 [male mating behavior] GO:0060999 [positive regulation of dendritic spine development] GO:0061351 [neural precursor cell proliferation] GO:0070062 [extracellular exosome] Show all	593 aa 63.5 kDa	Yes	0
GRN-002 ENSP00000467616 ENST00000589265	K7EQ05 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043231 [intracellular membrane-bounded organelle] Show all	436 aa 46.8 kDa	Yes	0
GRN-003 ENSP00000465673 ENST00000586443	K7EKL3 [Direct mapping] Granulins Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		388 aa 41.2 kDa	No	0
GRN-005 ENSP00000466956 ENST00000589536	K7ENI2 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 11.5 kDa	Yes	0
GRN-006 ENSP00000466271 ENST00000587109	K7ELY1 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 6.6 kDa	Yes	0
GRN-007 ENSP00000465518 ENST00000587518	K7EK92 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 14.3 kDa	Yes	0
GRN-008 ENSP00000466405 ENST00000593167	K7EM89 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 15.6 kDa	Yes	0
GRN-009 ENSP00000467745 ENST00000585512	K7EQA7 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 3.8 kDa	Yes	0
GRN-010 ENSP00000467870 ENST00000592783	K7EQK6 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		142 aa 14.9 kDa	Yes	0
GRN-011 ENSP00000467022 ENST00000591740	K7ENN1 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		135 aa 14.1 kDa	Yes	0
GRN-013 ENSP00000465375 ENST00000588143	K7EJY4 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 17.1 kDa	Yes	0
GRN-016 ENSP00000467431 ENST00000587387	K7EPL0 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		191 aa 20.3 kDa	Yes	0
GRN-017 ENSP00000466611 ENST00000588237	K7EMR1 [Direct mapping] Granulins Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 18.1 kDa	Yes	0
GRN-022 ENSP00000467837 ENST00000586242	K7EQI0 [Direct mapping] Granulins Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.