Fields »
ABOUT
HELP
BLOG
SYNE2

GENERAL INFORMATION

Gene name

 SYNE2

Gene description

 Spectrin repeat containing, nuclear envelope 2

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear membranous expression in several different cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003435 , HPA050204
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SYNE2 (HGNC Symbol)

Synonyms

 DKFZP434H2235, KIAA1011, Nesp2, Nesprin-2, NUA, NUANCE, SYNE-2

Description

 Spectrin repeat containing, nuclear envelope 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

 14

Cytoband

 q23.2

Chromosome location (bp)

 63852983 - 64226433

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000054654 (version 83.38)

Entrez gene

 23224

UniProt

 Q8WXH0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXH0

Antibodypedia

 SYNE2 antibodies

PROTEIN BROWSER
«
SYNE2-001
SYNE2-002
SYNE2-004
SYNE2-005
SYNE2-006
SYNE2-007
SYNE2-009
SYNE2-011
SYNE2-014
SYNE2-017
SYNE2-025
SYNE2-026
SYNE2-201
SYNE2-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYNE2-001
ENSP00000341781
ENST00000344113
Q8WXH0 [Direct mapping]
Nesprin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005925 [focal adhesion]
GO:0007097 [nuclear migration]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030335 [positive regulation of cell migration]
GO:0031022 [nuclear migration along microfilament]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031965 [nuclear membrane]
GO:0031981 [nuclear lumen]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034993 [LINC complex]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051642 [centrosome localization]
GO:0070062 [extracellular exosome]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 6885 aa
796.4 kDa 		No 1
SYNE2-002
ENSP00000452570
ENST00000554584
G3V5X4 [Direct mapping]
Nesprin-2
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0016235 [aggresome]
GO:0031965 [nuclear membrane]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 6818 aa
787.7 kDa 		No 0
SYNE2-004
ENSP00000344528
ENST00000341472
Q8WXH0 [Direct mapping]
Nesprin-2
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005925 [focal adhesion]
GO:0007097 [nuclear migration]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030335 [positive regulation of cell migration]
GO:0031022 [nuclear migration along microfilament]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031965 [nuclear membrane]
GO:0031981 [nuclear lumen]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034993 [LINC complex]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051642 [centrosome localization]
GO:0070062 [extracellular exosome]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 285 aa
32.2 kDa 		No 0
SYNE2-005
ENSP00000450605
ENST00000554805
A0A0C4DH87 [Direct mapping]
Nesprin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 668 aa
75.7 kDa 		No 1
SYNE2-006
ENSP00000391937
ENST00000458046
Q8WXH0 [Direct mapping]
Nesprin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005925 [focal adhesion]
GO:0007097 [nuclear migration]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030335 [positive regulation of cell migration]
GO:0031022 [nuclear migration along microfilament]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031965 [nuclear membrane]
GO:0031981 [nuclear lumen]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034993 [LINC complex]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051642 [centrosome localization]
GO:0070062 [extracellular exosome]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 556 aa
62.2 kDa 		No 1
SYNE2-007
ENSP00000396794
ENST00000441438
Q8WXH0 [Direct mapping]
Nesprin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005925 [focal adhesion]
GO:0007097 [nuclear migration]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030335 [positive regulation of cell migration]
GO:0031022 [nuclear migration along microfilament]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031965 [nuclear membrane]
GO:0031981 [nuclear lumen]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034993 [LINC complex]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051642 [centrosome localization]
GO:0070062 [extracellular exosome]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 429 aa
48.2 kDa 		No 1
SYNE2-009
ENSP00000451009
ENST00000555022
Q8WXH0 [Direct mapping]
Nesprin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005925 [focal adhesion]
GO:0007097 [nuclear migration]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030335 [positive regulation of cell migration]
GO:0031022 [nuclear migration along microfilament]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031965 [nuclear membrane]
GO:0031981 [nuclear lumen]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034993 [LINC complex]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051642 [centrosome localization]
GO:0070062 [extracellular exosome]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 763 aa
87.4 kDa 		No 1
SYNE2-011
ENSP00000450831
ENST00000555002
A0A0C4DGK3 [Direct mapping]
Nesprin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 3541 aa
408.7 kDa 		No 1
SYNE2-014
ENSP00000378249
ENST00000394768
Q8WXH0 [Direct mapping]
Nesprin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005925 [focal adhesion]
GO:0007097 [nuclear migration]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030335 [positive regulation of cell migration]
GO:0031022 [nuclear migration along microfilament]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031965 [nuclear membrane]
GO:0031981 [nuclear lumen]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034993 [LINC complex]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051642 [centrosome localization]
GO:0070062 [extracellular exosome]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 3270 aa
377.2 kDa 		No 1
SYNE2-017
ENSP00000452298
ENST00000556906
G3V5D3 [Direct mapping]
Nesprin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 162 aa
19.3 kDa 		No 0
SYNE2-025
ENSP00000451520
ENST00000553308
G3V403 [Direct mapping]
Nesprin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 172 aa
18.8 kDa 		No 0
SYNE2-026
ENSP00000452434
ENST00000553455
G3V5N1 [Direct mapping]
Nesprin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 214 aa
24.5 kDa 		No 0
SYNE2-201
ENSP00000349969
ENST00000357395
A0A0A0MRE3 [Direct mapping]
Nesprin-2
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
Show all
 6824 aa
788.4 kDa 		No 0
SYNE2-202
ENSP00000350719
ENST00000358025
Q8WXH0 [Direct mapping]
Nesprin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005925 [focal adhesion]
GO:0006998 [nuclear envelope organization]
GO:0007097 [nuclear migration]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0010761 [fibroblast migration]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016529 [sarcoplasmic reticulum]
GO:0030016 [myofibril]
GO:0030018 [Z disc]
GO:0030335 [positive regulation of cell migration]
GO:0031022 [nuclear migration along microfilament]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031965 [nuclear membrane]
GO:0031981 [nuclear lumen]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034504 [protein localization to nucleus]
GO:0034993 [LINC complex]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051642 [centrosome localization]
GO:0070062 [extracellular exosome]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 6907 aa
798.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.