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ACTN1
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ACTN1

Gene description

Actinin, alpha 1

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

High cytoplasmic and membrane expression in glandular epithelia and neuronal cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Approved based on 1 antibody.
HPA006035
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0200400600800TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin050100150200RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina02004006008001,0001,200Tags Per Million

GENE INFORMATION

Gene name

ACTN1

Synonyms

Description

Actinin, alpha 1 (HGNC Symbol)

Entrez gene summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q24.1

Chromosome location (bp)

68874143 - 68979440

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000072110 (version 83.38)

Entrez gene

87

UniProt

P12814 (UniProt - Evidence at protein level)

neXtProt

NX_P12814

Antibodypedia

ACTN1 antibodies

PROTEIN BROWSER

«
ACTN1-001
ACTN1-002
ACTN1-005
ACTN1-006
ACTN1-007
ACTN1-011
ACTN1-012
ACTN1-013
ACTN1-014
ACTN1-015
ACTN1-016
ACTN1-019
ACTN1-020
ACTN1-022
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACTN1-001
ENSP00000193403
ENST00000193403
P12814 [Direct mapping]
Alpha-actinin-1
A0A024R694 [Target identity:100%; Query identity:100%]
Actinin, alpha 1, isoform CRA_a
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0002576 [platelet degranulation]
GO:0003725 [double-stranded RNA binding]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0017166 [vinculin binding]
GO:0030018 [Z disc]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030220 [platelet formation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0031143 [pseudopodium]
GO:0034329 [cell junction assembly]
GO:0036344 [platelet morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0044325 [ion channel binding]
GO:0048041 [focal adhesion assembly]
GO:0051015 [actin filament binding]
GO:0051271 [negative regulation of cellular component movement]
GO:0051639 [actin filament network formation]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:1903506 [regulation of nucleic acid-templated transcription]
Show all
892 aa
103.1 kDa
No 0
ACTN1-002
ENSP00000414272
ENST00000438964
P12814 [Direct mapping]
Alpha-actinin-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0002576 [platelet degranulation]
GO:0003725 [double-stranded RNA binding]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0017166 [vinculin binding]
GO:0030018 [Z disc]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030220 [platelet formation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0031143 [pseudopodium]
GO:0034329 [cell junction assembly]
GO:0036344 [platelet morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0044325 [ion channel binding]
GO:0048041 [focal adhesion assembly]
GO:0051015 [actin filament binding]
GO:0051271 [negative regulation of cellular component movement]
GO:0051639 [actin filament network formation]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:1903506 [regulation of nucleic acid-templated transcription]
Show all
887 aa
102.7 kDa
No 0
ACTN1-005
ENSP00000377941
ENST00000394419
P12814 [Direct mapping]
Alpha-actinin-1
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0002576 [platelet degranulation]
GO:0003725 [double-stranded RNA binding]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005911 [cell-cell junction]
GO:0005916 [fascia adherens]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0017166 [vinculin binding]
GO:0030018 [Z disc]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030220 [platelet formation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0031143 [pseudopodium]
GO:0034329 [cell junction assembly]
GO:0036344 [platelet morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0044325 [ion channel binding]
GO:0048041 [focal adhesion assembly]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051271 [negative regulation of cellular component movement]
GO:0051639 [actin filament network formation]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:1903506 [regulation of nucleic acid-templated transcription]
Show all
914 aa
105.6 kDa
No 0
ACTN1-006
ENSP00000439828
ENST00000538545
P12814 [Direct mapping]
Alpha-actinin-1
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0002576 [platelet degranulation]
GO:0003725 [double-stranded RNA binding]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0017166 [vinculin binding]
GO:0030018 [Z disc]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030220 [platelet formation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0031143 [pseudopodium]
GO:0034329 [cell junction assembly]
GO:0036344 [platelet morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0044325 [ion channel binding]
GO:0048041 [focal adhesion assembly]
GO:0051015 [actin filament binding]
GO:0051271 [negative regulation of cellular component movement]
GO:0051639 [actin filament network formation]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:1903506 [regulation of nucleic acid-templated transcription]
Show all
930 aa
107.1 kDa
No 0
ACTN1-007
ENSP00000366035
ENST00000376839
H9KV75 [Direct mapping]
Alpha-actinin-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
Show all
822 aa
94.8 kDa
No 0
ACTN1-011
ENSP00000450764
ENST00000556433
G3V2N5 [Direct mapping]
Alpha-actinin-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
Show all
261 aa
29.6 kDa
No 0
ACTN1-012
ENSP00000450903
ENST00000555616
G3V2W4 [Direct mapping]
Alpha-actinin-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
Show all
238 aa
27.1 kDa
No 0
ACTN1-013
ENSP00000451086
ENST00000553659
G3V380 [Direct mapping]
Alpha-actinin-1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
Show all
72 aa
8.2 kDa
No 0
ACTN1-014
ENSP00000452423
ENST00000556571
G3V5M4 [Direct mapping]
Alpha-actinin-1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
Show all
126 aa
14 kDa
No 0
ACTN1-015
ENSP00000450925
ENST00000553370
G3V2X9 [Direct mapping]
Alpha-actinin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
Show all
144 aa
16.3 kDa
No 0
ACTN1-016
ENSP00000450618
ENST00000553779
G3V2E8 [Direct mapping]
Alpha-actinin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
Show all
85 aa
9.4 kDa
No 0
ACTN1-019
ENSP00000444422
ENST00000544964
H7C5W8 [Direct mapping]
Alpha-actinin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
Show all
297 aa
34.3 kDa
No 0
ACTN1-020
ENSP00000450625
ENST00000553290
H0YJ11 [Direct mapping]
Alpha-actinin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
Show all
207 aa
24.3 kDa
No 0
ACTN1-022
ENSP00000452254
ENST00000555075
H0YJW3 [Direct mapping]
Alpha-actinin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
Show all
251 aa
28.8 kDa
No 0

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