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EZR
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

EZR

Gene description

Ezrin

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA021616 , CAB004035 , CAB047324
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0100200300400500600TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin020406080100120140RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0100200300400500600Tags Per Million

GENE INFORMATION

Gene name

EZR (HGNC Symbol)

Synonyms

VIL2

Description

Ezrin (HGNC Symbol)

Entrez gene summary

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q25.3

Chromosome location (bp)

158765741 - 158819412

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000092820 (version 83.38)

Entrez gene

7430

UniProt

P15311 (UniProt - Evidence at protein level)

neXtProt

NX_P15311

Antibodypedia

EZR antibodies

PROTEIN BROWSER

EZR-001
EZR-002
EZR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EZR-001
ENSP00000356042
ENST00000367075
P15311 [Direct mapping]
Ezrin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001726 [ruffle]
GO:0001772 [immunological synapse]
GO:0001931 [uropod]
GO:0001951 [intestinal D-glucose absorption]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005903 [brush border]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019904 [protein domain specific binding]
GO:0022614 [membrane to membrane docking]
GO:0030033 [microvillus assembly]
GO:0030175 [filopodium]
GO:0030315 [T-tubule]
GO:0030855 [epithelial cell differentiation]
GO:0030863 [cortical cytoskeleton]
GO:0030953 [astral microtubule organization]
GO:0031528 [microvillus membrane]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
GO:0032532 [regulation of microvillus length]
GO:0032587 [ruffle membrane]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034629 [cellular protein complex localization]
GO:0035088 [establishment or maintenance of apical/basal cell polarity]
GO:0036064 [ciliary basal body]
GO:0036398 [TCR signalosome]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042995 [cell projection]
GO:0043209 [myelin sheath]
GO:0043622 [cortical microtubule organization]
GO:0044297 [cell body]
GO:0044393 [microspike]
GO:0044548 [S100 protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0044853 [plasma membrane raft]
GO:0045121 [membrane raft]
GO:0045177 [apical part of cell]
GO:0046847 [filopodium assembly]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051117 [ATPase binding]
GO:0051286 [cell tip]
GO:0051660 [establishment of centrosome localization]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071320 [cellular response to cAMP]
GO:0071944 [cell periphery]
GO:0072697 [protein localization to cell cortex]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097449 [astrocyte projection]
GO:0097454 [Schwann cell microvillus]
GO:0098592 [cytoplasmic side of apical plasma membrane]
GO:1900041 [negative regulation of interleukin-2 secretion]
GO:1902115 [regulation of organelle assembly]
GO:1902896 [terminal web assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903753 [negative regulation of p38MAPK cascade]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
586 aa
69.4 kDa
No 0
EZR-002
ENSP00000338934
ENST00000337147
P15311 [Direct mapping]
Ezrin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001726 [ruffle]
GO:0001772 [immunological synapse]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005903 [brush border]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019904 [protein domain specific binding]
GO:0022614 [membrane to membrane docking]
GO:0030033 [microvillus assembly]
GO:0030175 [filopodium]
GO:0030863 [cortical cytoskeleton]
GO:0030953 [astral microtubule organization]
GO:0031528 [microvillus membrane]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034629 [cellular protein complex localization]
GO:0036398 [TCR signalosome]
GO:0042995 [cell projection]
GO:0043622 [cortical microtubule organization]
GO:0044548 [S100 protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0044853 [plasma membrane raft]
GO:0045177 [apical part of cell]
GO:0046847 [filopodium assembly]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051117 [ATPase binding]
GO:0051660 [establishment of centrosome localization]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071320 [cellular response to cAMP]
GO:0071944 [cell periphery]
GO:0072697 [protein localization to cell cortex]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0098592 [cytoplasmic side of apical plasma membrane]
GO:1900041 [negative regulation of interleukin-2 secretion]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903753 [negative regulation of p38MAPK cascade]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
586 aa
69.4 kDa
No 0
EZR-201
ENSP00000376016
ENST00000392177
E7EQR4 [Direct mapping]
Ezrin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
586 aa
69.4 kDa
No 0

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