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Gene name

Class

Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

Score

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Antibodies

Column

 
 
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HDAC6
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

HDAC6

Gene description

Histone deacetylase 6

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most cell types, most abundant in renal tubules and cells in seminiferus ducts.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 3 antibodies.
HPA003714 , HPA026321 , CAB004236
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

HDAC6 (HGNC Symbol)

Synonyms

FLJ16239, HD6, JM21, KIAA0901, PPP1R90

Description

Histone deacetylase 6 (HGNC Symbol)

Entrez gene summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

p11.23

Chromosome location (bp)

48801377 - 48824982

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000094631 (version 83.38)

Entrez gene

10013

UniProt

Q9UBN7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBN7

Antibodypedia

HDAC6 antibodies

PROTEIN BROWSER

«
HDAC6-001
HDAC6-007
HDAC6-015
HDAC6-016
HDAC6-017
HDAC6-020
HDAC6-021
HDAC6-023
HDAC6-028
HDAC6-030
HDAC6-031
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HDAC6-001
ENSP00000334061
ENST00000334136
Q9UBN7 [Direct mapping]
Histone deacetylase 6
A0A024QZ26 [Target identity:100%; Query identity:100%]
Histone deacetylase 6, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000209 [protein polyubiquitination]
GO:0001047 [core promoter binding]
GO:0003779 [actin binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0005901 [caveola]
GO:0006351 [transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006515 [misfolded or incompletely synthesized protein catabolic process]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0008013 [beta-catenin binding]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0009636 [response to toxic substance]
GO:0009967 [positive regulation of signal transduction]
GO:0010033 [response to organic substance]
GO:0010469 [regulation of receptor activity]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010727 [negative regulation of hydrogen peroxide metabolic process]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0016234 [inclusion body]
GO:0016235 [aggresome]
GO:0016236 [macroautophagy]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0030286 [dynein complex]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031252 [cell leading edge]
GO:0031593 [polyubiquitin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032418 [lysosome localization]
GO:0034605 [cellular response to heat]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035967 [cellular response to topologically incorrect protein]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042826 [histone deacetylase binding]
GO:0042903 [tubulin deacetylase activity]
GO:0043014 [alpha-tubulin binding]
GO:0043130 [ubiquitin binding]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043204 [perikaryon]
GO:0043234 [protein complex]
GO:0043241 [protein complex disassembly]
GO:0043242 [negative regulation of protein complex disassembly]
GO:0045598 [regulation of fat cell differentiation]
GO:0045861 [negative regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048487 [beta-tubulin binding]
GO:0051354 [negative regulation of oxidoreductase activity]
GO:0051646 [mitochondrion localization]
GO:0051787 [misfolded protein binding]
GO:0051788 [response to misfolded protein]
GO:0051879 [Hsp90 protein binding]
GO:0060632 [regulation of microtubule-based movement]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0070201 [regulation of establishment of protein localization]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070840 [dynein complex binding]
GO:0070842 [aggresome assembly]
GO:0070845 [polyubiquitinated misfolded protein transport]
GO:0070846 [Hsp90 deacetylation]
GO:0070848 [response to growth factor]
GO:0070932 [histone H3 deacetylation]
GO:0071218 [cellular response to misfolded protein]
GO:0090035 [positive regulation of chaperone-mediated protein complex assembly]
GO:0090042 [tubulin deacetylation]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901300 [positive regulation of hydrogen peroxide-mediated programmed cell death]
Show all
1215 aa
131.4 kDa
No 0
HDAC6-007
ENSP00000365831
ENST00000376643
A6NDI8 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
210 aa
23.4 kDa
No 0
HDAC6-015
ENSP00000402189
ENST00000426196
E7EPS2 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
269 aa
30.3 kDa
No 0
HDAC6-016
ENSP00000397697
ENST00000430858
H7C0Z9 [Direct mapping]
Histone deacetylase 6
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
84 aa
8.7 kDa
No 0
HDAC6-017
ENSP00000365804
ENST00000376619
Q9UBN7 [Direct mapping]
Histone deacetylase 6
A0A024QZ26 [Target identity:100%; Query identity:100%]
Histone deacetylase 6, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0001047 [core promoter binding]
GO:0003779 [actin binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005901 [caveola]
GO:0006351 [transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0006515 [misfolded or incompletely synthesized protein catabolic process]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0008013 [beta-catenin binding]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0009636 [response to toxic substance]
GO:0009967 [positive regulation of signal transduction]
GO:0010033 [response to organic substance]
GO:0010469 [regulation of receptor activity]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010727 [negative regulation of hydrogen peroxide metabolic process]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0016234 [inclusion body]
GO:0016235 [aggresome]
GO:0016236 [macroautophagy]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0030286 [dynein complex]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031252 [cell leading edge]
GO:0031593 [polyubiquitin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032418 [lysosome localization]
GO:0034605 [cellular response to heat]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035967 [cellular response to topologically incorrect protein]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042826 [histone deacetylase binding]
GO:0042903 [tubulin deacetylase activity]
GO:0043014 [alpha-tubulin binding]
GO:0043204 [perikaryon]
GO:0043242 [negative regulation of protein complex disassembly]
GO:0045861 [negative regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051354 [negative regulation of oxidoreductase activity]
GO:0051787 [misfolded protein binding]
GO:0051788 [response to misfolded protein]
GO:0051879 [Hsp90 protein binding]
GO:0060632 [regulation of microtubule-based movement]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070840 [dynein complex binding]
GO:0070842 [aggresome assembly]
GO:0070845 [polyubiquitinated misfolded protein transport]
GO:0070846 [Hsp90 deacetylation]
GO:0070848 [response to growth factor]
GO:0070932 [histone H3 deacetylation]
GO:0090035 [positive regulation of chaperone-mediated protein complex assembly]
GO:0090042 [tubulin deacetylation]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901300 [positive regulation of hydrogen peroxide-mediated programmed cell death]
Show all
1215 aa
131.4 kDa
No 0
HDAC6-020
ENSP00000392815
ENST00000423941
C9J172 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
142 aa
15.9 kDa
No 0
HDAC6-021
ENSP00000403370
ENST00000438518
C9JEF4 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
51 aa
5.6 kDa
No 0
HDAC6-023
ENSP00000365795
ENST00000376610
A6NDI8 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
210 aa
23.4 kDa
No 0
HDAC6-028
ENSP00000393916
ENST00000441703
E9PEH1 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
161 aa
18.2 kDa
No 0
HDAC6-030
ENSP00000402751
ENST00000443563
E7EP63 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
167 aa
18.9 kDa
No 0
HDAC6-031
ENSP00000394377
ENST00000440653
E7ER52 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
171 aa
19.3 kDa
No 0

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