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Protein phosphatase 2, catalytic subunit, beta isozyme (HGNC Symbol)
Entrez gene summary
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000159 [protein phosphatase type 2A complex] GO:0000775 [chromosome, centromeric region] GO:0000922 [spindle pole] GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0008022 [protein C-terminus binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008637 [apoptotic mitochondrial changes] GO:0010468 [regulation of gene expression] GO:0016787 [hydrolase activity] GO:0034976 [response to endoplasmic reticulum stress] GO:0042542 [response to hydrogen peroxide] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046580 [negative regulation of Ras protein signal transduction] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome]
