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AMPD2

GENERAL INFORMATION

Gene name

 AMPD2

Gene description

 Adenosine monophosphate deaminase 2

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, with highest expression in islets of Langerhans and neuronal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA027137 , HPA045760 , HPA050590
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
N/ACerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin010203040506070RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100120Tags Per Million

GENE INFORMATION

Gene name

 AMPD2 (HGNC Symbol)

Synonyms

 SPG63

Description

 Adenosine monophosphate deaminase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 109616104 - 109632051

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116337 (version 83.38)

Entrez gene

 271

UniProt

 Q01433 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01433

Antibodypedia

 AMPD2 antibodies

PROTEIN BROWSER
«
AMPD2-001
AMPD2-002
AMPD2-004
AMPD2-005
AMPD2-006
AMPD2-007
AMPD2-010
AMPD2-011
AMPD2-012
AMPD2-014
AMPD2-015
AMPD2-016
AMPD2-018
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AMPD2-001
ENSP00000345498
ENST00000342115
Q01433 [Direct mapping]
AMP deaminase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006188 [IMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019239 [deaminase activity]
GO:0032264 [IMP salvage]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052652 [cyclic purine nucleotide metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0097009 [energy homeostasis]
Show all
 798 aa
92.1 kDa 		No 0
AMPD2-002
ENSP00000358855
ENST00000369840
H0Y360 [Direct mapping]
AMP deaminase 2
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019239 [deaminase activity]
GO:0032264 [IMP salvage]
Show all
 861 aa
98.4 kDa 		No 0
AMPD2-004
ENSP00000432344
ENST00000474459
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1 aa
0.1 kDa 		No 0
AMPD2-005
ENSP00000436541
ENST00000528667
Q01433 [Direct mapping]
AMP deaminase 2
A0A024R098 [Target identity:100%; Query identity:100%]
Adenosine monophosphate deaminase 2 (Isoform L), isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006188 [IMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019239 [deaminase activity]
GO:0032264 [IMP salvage]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052652 [cyclic purine nucleotide metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0097009 [energy homeostasis]
Show all
 879 aa
100.7 kDa 		No 0
AMPD2-006
ENSP00000351573
ENST00000358729
Q01433 [Direct mapping]
AMP deaminase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006188 [IMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019239 [deaminase activity]
GO:0032264 [IMP salvage]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052652 [cyclic purine nucleotide metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0097009 [energy homeostasis]
Show all
 804 aa
92.9 kDa 		No 0
AMPD2-007
ENSP00000437164
ENST00000528454
Q01433 [Direct mapping]
AMP deaminase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006188 [IMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019239 [deaminase activity]
GO:0032264 [IMP salvage]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052652 [cyclic purine nucleotide metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0097009 [energy homeostasis]
Show all
 761 aa
88.3 kDa 		No 0
AMPD2-010
ENSP00000437025
ENST00000476688
H0YF16 [Direct mapping]
AMP deaminase 2
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019239 [deaminase activity]
GO:0032264 [IMP salvage]
Show all
 231 aa
26.3 kDa 		No 0
AMPD2-011
ENSP00000256578
ENST00000256578
Q01433 [Direct mapping]
AMP deaminase 2
A0A024R098 [Target identity:100%; Query identity:100%]
Adenosine monophosphate deaminase 2 (Isoform L), isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006188 [IMP biosynthetic process]
GO:0009117 [nucleotide metabolic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019239 [deaminase activity]
GO:0032264 [IMP salvage]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0046033 [AMP metabolic process]
GO:0046034 [ATP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046872 [metal ion binding]
GO:0052652 [cyclic purine nucleotide metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0097009 [energy homeostasis]
Show all
 879 aa
100.7 kDa 		No 0
AMPD2-012
ENSP00000377292
ENST00000393688
Q01433 [Direct mapping]
AMP deaminase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006188 [IMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019239 [deaminase activity]
GO:0032264 [IMP salvage]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052652 [cyclic purine nucleotide metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0097009 [energy homeostasis]
Show all
 760 aa
88.2 kDa 		No 0
AMPD2-014
ENSP00000433739
ENST00000531734
E9PJF6 [Direct mapping]
AMP deaminase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0032264 [IMP salvage]
Show all
 103 aa
11.6 kDa 		No 0
AMPD2-015
ENSP00000431975
ENST00000531203
E9PIJ1 [Direct mapping]
AMP deaminase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0032264 [IMP salvage]
Show all
 87 aa
10.2 kDa 		No 0
AMPD2-016
ENSP00000436303
ENST00000469039
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1 aa
0.1 kDa 		No 0
AMPD2-018
ENSP00000431904
ENST00000527846
H0YCL9 [Direct mapping]
AMP deaminase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003876 [AMP deaminase activity]
GO:0032264 [IMP salvage]
Show all
 195 aa
21.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.