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ZEB1

GENERAL INFORMATION

Gene name

 ZEB1

Gene description

 Zinc finger E-box binding homeobox 1

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several cell types, highly abundant in smooth muscle cells, cardiac and skeletal myocytes and other various cells in tissue stroma.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA027524 , CAB058686
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ZEB1 (HGNC Symbol)

Synonyms

 AREB6, BZP, FECD6, NIL-2-A, PPCD3, TCF8, ZEB, Zfhep, Zfhx1a

Description

 Zinc finger E-box binding homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]

Chromosome

 10

Cytoband

 p11.22

Chromosome location (bp)

 31318495 - 31529814

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148516 (version 83.38)

Entrez gene

 6935

UniProt

 P37275 (UniProt - Evidence at protein level)

neXtProt

 NX_P37275

Antibodypedia

 ZEB1 antibodies

PROTEIN BROWSER
ZEB1-002
ZEB1-003
ZEB1-004
ZEB1-012
ZEB1-016
ZEB1-018
ZEB1-020
ZEB1-201
ZEB1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZEB1-002
ENSP00000452787
ENST00000560721
P37275 [Direct mapping]
Zinc finger E-box-binding homeobox 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070888 [E-box binding]
Show all
 1104 aa
122 kDa 		No 0
ZEB1-003
ENSP00000453970
ENST00000558440
H0YND9 [Direct mapping]
Zinc finger E-box-binding homeobox 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 288 aa
32.9 kDa 		No 0
ZEB1-004
ENSP00000415961
ENST00000424869
F6TDF5 [Direct mapping]
Zinc finger E-box-binding homeobox 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 289 aa
32.9 kDa 		No 0
ZEB1-012
ENSP00000453674
ENST00000559476
H0YMN2 [Direct mapping]
Zinc finger E-box-binding homeobox 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 277 aa
31.5 kDa 		No 0
ZEB1-016
ENSP00000444891
ENST00000542815
P37275 [Direct mapping]
Zinc finger E-box-binding homeobox 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070888 [E-box binding]
Show all
 1057 aa
116.6 kDa 		No 0
ZEB1-018
ENSP00000319248
ENST00000320985
P37275 [Direct mapping]
Zinc finger E-box-binding homeobox 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070888 [E-box binding]
Show all
 1124 aa
124.1 kDa 		No 0
ZEB1-020
ENSP00000453559
ENST00000561212
H0YMD3 [Direct mapping]
Zinc finger E-box-binding homeobox 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 274 aa
29.8 kDa 		No 0
ZEB1-201
ENSP00000354487
ENST00000361642
P37275 [Direct mapping]
Zinc finger E-box-binding homeobox 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0007389 [pattern specification process]
GO:0007417 [central nervous system development]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010464 [regulation of mesenchymal cell proliferation]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0033081 [regulation of T cell differentiation in thymus]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048513 [organ development]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0048598 [embryonic morphogenesis]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0048752 [semicircular canal morphogenesis]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051216 [cartilage development]
GO:0070888 [E-box binding]
GO:0071230 [cellular response to amino acid stimulus]
GO:0090103 [cochlea morphogenesis]
Show all
 1125 aa
124.1 kDa 		No 0
ZEB1-202
ENSP00000391612
ENST00000446923
P37275 [Direct mapping]
Zinc finger E-box-binding homeobox 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070888 [E-box binding]
Show all
 1108 aa
122.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.