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STIM1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

STIM1

Gene description

Stromal interaction molecule 1

Protein class

Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

13
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression at variable levels in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 4 antibodies.
HPA011088 , HPA012123 , CAB037128 , CAB037288
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin051015202530RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100120140Tags Per Million

GENE INFORMATION

Gene name

STIM1 (HGNC Symbol)

Synonyms

D11S4896E, GOK

Description

Stromal interaction molecule 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

3854527 - 4093210

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167323 (version 83.38)

Entrez gene

6786

UniProt

Q13586 (UniProt - Evidence at protein level)

neXtProt

NX_Q13586

Antibodypedia

STIM1 antibodies

PROTEIN BROWSER

«
STIM1-001
STIM1-002
STIM1-003
STIM1-004
STIM1-005
STIM1-006
STIM1-007
STIM1-010
STIM1-015
STIM1-016
STIM1-017
STIM1-018
STIM1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STIM1-001
ENSP00000300737
ENST00000300737
Q13586 [Direct mapping]
Stromal interaction molecule 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005246 [calcium channel regulator activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005874 [microtubule]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0007596 [blood coagulation]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0042802 [identical protein binding]
GO:0051010 [microtubule plus-end binding]
GO:0051924 [regulation of calcium ion transport]
GO:0070166 [enamel mineralization]
Show all
685 aa
77.4 kDa
Yes 1
STIM1-002
ENSP00000436208
ENST00000527651
Q13586 [Direct mapping]
Stromal interaction molecule 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005246 [calcium channel regulator activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005874 [microtubule]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0007596 [blood coagulation]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0042802 [identical protein binding]
GO:0051010 [microtubule plus-end binding]
GO:0051924 [regulation of calcium ion transport]
GO:0070166 [enamel mineralization]
Show all
540 aa
62.1 kDa
Yes 1
STIM1-003
ENSP00000434767
ENST00000533977
E9PNJ4 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005783 [endoplasmic reticulum]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
512 aa
57.6 kDa
No 1
STIM1-004
ENSP00000432210
ENST00000525403
E9PRZ7 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
110 aa
12.9 kDa
No 0
STIM1-005
ENSP00000433949
ENST00000532919
E9PIQ8 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
139 aa
16.2 kDa
No 0
STIM1-006
ENSP00000432383
ENST00000532990
E9PR07 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
67 aa
7.9 kDa
No 0
STIM1-007
ENSP00000431191
ENST00000525055
E9PMB4 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
83 aa
9.9 kDa
No 0
STIM1-010
ENSP00000433266
ENST00000526596
H0YDB2 [Direct mapping]
Stromal interaction molecule 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
405 aa
45.3 kDa
No 0
STIM1-015
ENSP00000434848
ENST00000532610
E9PN27 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
133 aa
15.4 kDa
No 0
STIM1-016
ENSP00000432378
ENST00000528656
E9PR09 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
117 aa
13.7 kDa
No 0
STIM1-017
ENSP00000434200
ENST00000524822
E9PRE4 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
54 aa
6.3 kDa
No 0
STIM1-018
ENSP00000431878
ENST00000530554
E9PJ19 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
81 aa
9.7 kDa
No 0
STIM1-201
ENSP00000478059
ENST00000616714
G0XQ39 [Direct mapping]
STIM1L; Stromal interaction molecule 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002115 [store-operated calcium entry]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0006812 [cation transport]
GO:0014902 [myotube differentiation]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0043234 [protein complex]
Show all
791 aa
88.6 kDa
Yes 1

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